Renewed fighting in Gaza has stretched into a second day after talks to extend a week-old temporary truce with Hamas collapsed and mediators said Israeli bombardments were complicating attempts to again pause hostilities.

Eastern areas of Khan Younis in southern Gaza came under intense bombardment as the truce deadline lapsed shortly after dawn on Friday, with columns of smoke rising into the sky, Reuters journalists in the city said.

Israel said its ground, air and naval forces struck more than 200 “terror targets” in Gaza. By Friday evening, health officials in the coastal strip said Israeli strikes had killed 184 people, wounded at least 589 others and hit more than 20 houses.

Residents took to the road with belongings heaped up in carts, searching for shelter further west.